lead dbs matlab toolbox Search Results


least-squares fitting algorithm  (MathWorks Inc)
90
MathWorks Inc least-squares fitting algorithm
Least Squares Fitting Algorithm, supplied by MathWorks Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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matlab-simulink utility  (MathWorks Inc)
90
MathWorks Inc matlab-simulink utility
Matlab Simulink Utility, supplied by MathWorks Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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lead-dbs  (MathWorks Inc)
90
MathWorks Inc lead-dbs
(a, b) 3D source-reconstruction in MNI space. N = 20. White crosses mark the cortical ROIs selected for further analysis based on the strongest relative change in power ( a ) and the strongest absolute change in coherence ( b ). (c) All patients’ <t>DBS</t> <t>electrodes,</t> localized with Lead-DBS.
Lead Dbs, supplied by MathWorks Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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automated tw analysis software  (MathWorks Inc)
90
MathWorks Inc automated tw analysis software
Subject characteristics, inclusion, and exclusion criteria.
Automated Tw Analysis Software, supplied by MathWorks Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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lead-dbs matlab toolbox  (MathWorks Inc)
90
MathWorks Inc lead-dbs matlab toolbox
Subject characteristics, inclusion, and exclusion criteria.
Lead Dbs Matlab Toolbox, supplied by MathWorks Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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nonlinear solvers fmincon  (MathWorks Inc)
90
MathWorks Inc nonlinear solvers fmincon
Subject characteristics, inclusion, and exclusion criteria.
Nonlinear Solvers Fmincon, supplied by MathWorks Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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matlab toolbox-leaddbs  (MathWorks Inc)
96
MathWorks Inc matlab toolbox-leaddbs
a DBS lead construction via <t>LeadDBS</t> toolbox. Bilateral DBS leads accurately targeted the STN region (orange area). b , c The SOD level was obviously increased after patients received STN-DBS for six months ( P = 0.0455), nevertheless, GSH expression did not change in the same period ( P = 0.3025) ( n = 8 per time point; paired-T test). d , e Regardless of whether patients were on or off medication, the MDS-UPDRS III scores were significantly reduced after the operation ( n = 7 per time point; d: P = 0.0329; e: P = 0.0002; paired-T test). f , g There was no significant relationship between changes in antioxidant enzymes [SOD ( P = 0.8763) or GSH ( P = 0.7926)] and change in MDS-UPDRS III ( \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\frac{{({Preoperative}\,{\rm{MDS}}-{\rm{UPDRS}})}_{{med}-{off}}-{({Postoperative}\,{MDS}\,{UPDRS})}_{{stm}-{on},\,{med}-{off}}}{{({Preoperative}\,{\rm{MDS}}-{\rm{UPDRS}})}_{{med}-{off}}}\times 100 \%$$\end{document} ( P r e o p e r a t i v e MDS − UPDRS ) m e d − o f f − ( P o s t o p e r a t i v e M D S U P D R S ) s t m − o n , m e d − o f f ( P r e o p e r a t i v e MDS − UPDRS ) m e d − o f f × 100 % ) ( n = 7; Pearson correlation test). * P < 0.05; ** P < 0.01; *** P < 0.001; **** P < 0.0001. Error bars standard deviation of the mean, STN-DBS subthalamic nuclei deep brain stimulation, PD Parkinson’s disease, SOD superoxide dismutase, GSH glutathione, MDS-UPDRS Movement Disorder Society-Sponsored Revision of the Unified Parkinson’s Disease Rating Scale, ns not significant.
Matlab Toolbox Leaddbs, supplied by MathWorks Inc, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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lead acid batteries  (MathWorks Inc)
90
MathWorks Inc lead acid batteries
a DBS lead construction via <t>LeadDBS</t> toolbox. Bilateral DBS leads accurately targeted the STN region (orange area). b , c The SOD level was obviously increased after patients received STN-DBS for six months ( P = 0.0455), nevertheless, GSH expression did not change in the same period ( P = 0.3025) ( n = 8 per time point; paired-T test). d , e Regardless of whether patients were on or off medication, the MDS-UPDRS III scores were significantly reduced after the operation ( n = 7 per time point; d: P = 0.0329; e: P = 0.0002; paired-T test). f , g There was no significant relationship between changes in antioxidant enzymes [SOD ( P = 0.8763) or GSH ( P = 0.7926)] and change in MDS-UPDRS III ( \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\frac{{({Preoperative}\,{\rm{MDS}}-{\rm{UPDRS}})}_{{med}-{off}}-{({Postoperative}\,{MDS}\,{UPDRS})}_{{stm}-{on},\,{med}-{off}}}{{({Preoperative}\,{\rm{MDS}}-{\rm{UPDRS}})}_{{med}-{off}}}\times 100 \%$$\end{document} ( P r e o p e r a t i v e MDS − UPDRS ) m e d − o f f − ( P o s t o p e r a t i v e M D S U P D R S ) s t m − o n , m e d − o f f ( P r e o p e r a t i v e MDS − UPDRS ) m e d − o f f × 100 % ) ( n = 7; Pearson correlation test). * P < 0.05; ** P < 0.01; *** P < 0.001; **** P < 0.0001. Error bars standard deviation of the mean, STN-DBS subthalamic nuclei deep brain stimulation, PD Parkinson’s disease, SOD superoxide dismutase, GSH glutathione, MDS-UPDRS Movement Disorder Society-Sponsored Revision of the Unified Parkinson’s Disease Rating Scale, ns not significant.
Lead Acid Batteries, supplied by MathWorks Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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mvregress  (MathWorks Inc)
90
MathWorks Inc mvregress
a DBS lead construction via <t>LeadDBS</t> toolbox. Bilateral DBS leads accurately targeted the STN region (orange area). b , c The SOD level was obviously increased after patients received STN-DBS for six months ( P = 0.0455), nevertheless, GSH expression did not change in the same period ( P = 0.3025) ( n = 8 per time point; paired-T test). d , e Regardless of whether patients were on or off medication, the MDS-UPDRS III scores were significantly reduced after the operation ( n = 7 per time point; d: P = 0.0329; e: P = 0.0002; paired-T test). f , g There was no significant relationship between changes in antioxidant enzymes [SOD ( P = 0.8763) or GSH ( P = 0.7926)] and change in MDS-UPDRS III ( \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\frac{{({Preoperative}\,{\rm{MDS}}-{\rm{UPDRS}})}_{{med}-{off}}-{({Postoperative}\,{MDS}\,{UPDRS})}_{{stm}-{on},\,{med}-{off}}}{{({Preoperative}\,{\rm{MDS}}-{\rm{UPDRS}})}_{{med}-{off}}}\times 100 \%$$\end{document} ( P r e o p e r a t i v e MDS − UPDRS ) m e d − o f f − ( P o s t o p e r a t i v e M D S U P D R S ) s t m − o n , m e d − o f f ( P r e o p e r a t i v e MDS − UPDRS ) m e d − o f f × 100 % ) ( n = 7; Pearson correlation test). * P < 0.05; ** P < 0.01; *** P < 0.001; **** P < 0.0001. Error bars standard deviation of the mean, STN-DBS subthalamic nuclei deep brain stimulation, PD Parkinson’s disease, SOD superoxide dismutase, GSH glutathione, MDS-UPDRS Movement Disorder Society-Sponsored Revision of the Unified Parkinson’s Disease Rating Scale, ns not significant.
Mvregress, supplied by MathWorks Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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toolbox lead dbs  (MathWorks Inc)
96
MathWorks Inc toolbox lead dbs
a DBS lead construction via <t>LeadDBS</t> toolbox. Bilateral DBS leads accurately targeted the STN region (orange area). b , c The SOD level was obviously increased after patients received STN-DBS for six months ( P = 0.0455), nevertheless, GSH expression did not change in the same period ( P = 0.3025) ( n = 8 per time point; paired-T test). d , e Regardless of whether patients were on or off medication, the MDS-UPDRS III scores were significantly reduced after the operation ( n = 7 per time point; d: P = 0.0329; e: P = 0.0002; paired-T test). f , g There was no significant relationship between changes in antioxidant enzymes [SOD ( P = 0.8763) or GSH ( P = 0.7926)] and change in MDS-UPDRS III ( \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\frac{{({Preoperative}\,{\rm{MDS}}-{\rm{UPDRS}})}_{{med}-{off}}-{({Postoperative}\,{MDS}\,{UPDRS})}_{{stm}-{on},\,{med}-{off}}}{{({Preoperative}\,{\rm{MDS}}-{\rm{UPDRS}})}_{{med}-{off}}}\times 100 \%$$\end{document} ( P r e o p e r a t i v e MDS − UPDRS ) m e d − o f f − ( P o s t o p e r a t i v e M D S U P D R S ) s t m − o n , m e d − o f f ( P r e o p e r a t i v e MDS − UPDRS ) m e d − o f f × 100 % ) ( n = 7; Pearson correlation test). * P < 0.05; ** P < 0.01; *** P < 0.001; **** P < 0.0001. Error bars standard deviation of the mean, STN-DBS subthalamic nuclei deep brain stimulation, PD Parkinson’s disease, SOD superoxide dismutase, GSH glutathione, MDS-UPDRS Movement Disorder Society-Sponsored Revision of the Unified Parkinson’s Disease Rating Scale, ns not significant.
Toolbox Lead Dbs, supplied by MathWorks Inc, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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software tool (lead dbs, matlab)  (MathWorks Inc)
90
MathWorks Inc software tool (lead dbs, matlab)
a DBS lead construction via <t>LeadDBS</t> toolbox. Bilateral DBS leads accurately targeted the STN region (orange area). b , c The SOD level was obviously increased after patients received STN-DBS for six months ( P = 0.0455), nevertheless, GSH expression did not change in the same period ( P = 0.3025) ( n = 8 per time point; paired-T test). d , e Regardless of whether patients were on or off medication, the MDS-UPDRS III scores were significantly reduced after the operation ( n = 7 per time point; d: P = 0.0329; e: P = 0.0002; paired-T test). f , g There was no significant relationship between changes in antioxidant enzymes [SOD ( P = 0.8763) or GSH ( P = 0.7926)] and change in MDS-UPDRS III ( \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\frac{{({Preoperative}\,{\rm{MDS}}-{\rm{UPDRS}})}_{{med}-{off}}-{({Postoperative}\,{MDS}\,{UPDRS})}_{{stm}-{on},\,{med}-{off}}}{{({Preoperative}\,{\rm{MDS}}-{\rm{UPDRS}})}_{{med}-{off}}}\times 100 \%$$\end{document} ( P r e o p e r a t i v e MDS − UPDRS ) m e d − o f f − ( P o s t o p e r a t i v e M D S U P D R S ) s t m − o n , m e d − o f f ( P r e o p e r a t i v e MDS − UPDRS ) m e d − o f f × 100 % ) ( n = 7; Pearson correlation test). * P < 0.05; ** P < 0.01; *** P < 0.001; **** P < 0.0001. Error bars standard deviation of the mean, STN-DBS subthalamic nuclei deep brain stimulation, PD Parkinson’s disease, SOD superoxide dismutase, GSH glutathione, MDS-UPDRS Movement Disorder Society-Sponsored Revision of the Unified Parkinson’s Disease Rating Scale, ns not significant.
Software Tool (Lead Dbs, Matlab), supplied by MathWorks Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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toolbox lead dbs v2.5.3  (MathWorks Inc)
90
MathWorks Inc toolbox lead dbs v2.5.3
a DBS lead construction via <t>LeadDBS</t> toolbox. Bilateral DBS leads accurately targeted the STN region (orange area). b , c The SOD level was obviously increased after patients received STN-DBS for six months ( P = 0.0455), nevertheless, GSH expression did not change in the same period ( P = 0.3025) ( n = 8 per time point; paired-T test). d , e Regardless of whether patients were on or off medication, the MDS-UPDRS III scores were significantly reduced after the operation ( n = 7 per time point; d: P = 0.0329; e: P = 0.0002; paired-T test). f , g There was no significant relationship between changes in antioxidant enzymes [SOD ( P = 0.8763) or GSH ( P = 0.7926)] and change in MDS-UPDRS III ( \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\frac{{({Preoperative}\,{\rm{MDS}}-{\rm{UPDRS}})}_{{med}-{off}}-{({Postoperative}\,{MDS}\,{UPDRS})}_{{stm}-{on},\,{med}-{off}}}{{({Preoperative}\,{\rm{MDS}}-{\rm{UPDRS}})}_{{med}-{off}}}\times 100 \%$$\end{document} ( P r e o p e r a t i v e MDS − UPDRS ) m e d − o f f − ( P o s t o p e r a t i v e M D S U P D R S ) s t m − o n , m e d − o f f ( P r e o p e r a t i v e MDS − UPDRS ) m e d − o f f × 100 % ) ( n = 7; Pearson correlation test). * P < 0.05; ** P < 0.01; *** P < 0.001; **** P < 0.0001. Error bars standard deviation of the mean, STN-DBS subthalamic nuclei deep brain stimulation, PD Parkinson’s disease, SOD superoxide dismutase, GSH glutathione, MDS-UPDRS Movement Disorder Society-Sponsored Revision of the Unified Parkinson’s Disease Rating Scale, ns not significant.
Toolbox Lead Dbs V2.5.3, supplied by MathWorks Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


(a, b) 3D source-reconstruction in MNI space. N = 20. White crosses mark the cortical ROIs selected for further analysis based on the strongest relative change in power ( a ) and the strongest absolute change in coherence ( b ). (c) All patients’ DBS electrodes, localized with Lead-DBS.

Journal: bioRxiv

Article Title: Beta Waves in Action: Context-Dependent Modulations of Subthalamo-Cortical Synchronization during Rapid Reversals of Movement Direction

doi: 10.1101/2024.08.19.608624

Figure Lengend Snippet: (a, b) 3D source-reconstruction in MNI space. N = 20. White crosses mark the cortical ROIs selected for further analysis based on the strongest relative change in power ( a ) and the strongest absolute change in coherence ( b ). (c) All patients’ DBS electrodes, localized with Lead-DBS.

Article Snippet: The positions of DBS electrodes were localized with the MATLAB toolbox Lead-DBS ( ) using the patients’ pre-operative T1-and T2-weighted MRIs (Magnetom Trio MRI scanner, Siemens, Erlangen, Germany) and postoperative CT scans ( ).

Techniques:

Subject characteristics, inclusion, and exclusion criteria.

Journal: Annals of Noninvasive Electrocardiology

Article Title: The diagnostic role of T wave morphology biomarkers in congenital and acquired long QT syndrome: A systematic review

doi: 10.1111/anec.13015

Figure Lengend Snippet: Subject characteristics, inclusion, and exclusion criteria.

Article Snippet: Sugrue et al. ( ) , N/A , 12 lead ECG Bazett formula Automated TW analysis software (MATLAB) , Novel proprietary TW program Training and validation phases Manifest and concealed LQTS TW features vs. QTc Diagnostic accuracy: Sn, Sp, NPV, PPV , Discrimination accuracy TWM Lead V 6 : Manifest LQTS: 86.8% Concealed LQTS: 83.3% TW features: Tpeak‐Tend, left slope, COG x axis Sn: 83% (manifest), 76% (concealed) Sp: 91% (manifest), 91% (concealed) PPV: 90% (manifest), 89% (concealed) NPV: 84% (manifest), 79% (concealed).

Techniques: Control, Medications, Mutagenesis, Positive Control, Pregnancy Test (hCG) Assay

Summary of results for congenital long QT syndrome.

Journal: Annals of Noninvasive Electrocardiology

Article Title: The diagnostic role of T wave morphology biomarkers in congenital and acquired long QT syndrome: A systematic review

doi: 10.1111/anec.13015

Figure Lengend Snippet: Summary of results for congenital long QT syndrome.

Article Snippet: Sugrue et al. ( ) , N/A , 12 lead ECG Bazett formula Automated TW analysis software (MATLAB) , Novel proprietary TW program Training and validation phases Manifest and concealed LQTS TW features vs. QTc Diagnostic accuracy: Sn, Sp, NPV, PPV , Discrimination accuracy TWM Lead V 6 : Manifest LQTS: 86.8% Concealed LQTS: 83.3% TW features: Tpeak‐Tend, left slope, COG x axis Sn: 83% (manifest), 76% (concealed) Sp: 91% (manifest), 91% (concealed) PPV: 90% (manifest), 89% (concealed) NPV: 84% (manifest), 79% (concealed).

Techniques: Software, Comparison, Control, Extraction, Biomarker Discovery, Diagnostic Assay, Derivative Assay

Summary of results for acquired long QT syndrome.

Journal: Annals of Noninvasive Electrocardiology

Article Title: The diagnostic role of T wave morphology biomarkers in congenital and acquired long QT syndrome: A systematic review

doi: 10.1111/anec.13015

Figure Lengend Snippet: Summary of results for acquired long QT syndrome.

Article Snippet: Sugrue et al. ( ) , N/A , 12 lead ECG Bazett formula Automated TW analysis software (MATLAB) , Novel proprietary TW program Training and validation phases Manifest and concealed LQTS TW features vs. QTc Diagnostic accuracy: Sn, Sp, NPV, PPV , Discrimination accuracy TWM Lead V 6 : Manifest LQTS: 86.8% Concealed LQTS: 83.3% TW features: Tpeak‐Tend, left slope, COG x axis Sn: 83% (manifest), 76% (concealed) Sp: 91% (manifest), 91% (concealed) PPV: 90% (manifest), 89% (concealed) NPV: 84% (manifest), 79% (concealed).

Techniques: Diagnostic Assay, Software, Control, Clinical Proteomics, Biomarker Discovery, Plasmid Preparation, Patch Clamp, Blocking Assay, Concentration Assay, Mutagenesis

Selected T wave morphology analysis techniques. (a) ECG time intervals indicating specific T wave parameters, including Tpeak‐Tend interval (ms), T duration (ms), and T amplitude (mV). (bi) Application of sigmoidal classifiers demonstrated using Boltzmann sigmoidal functions: Upslope (red dotted line), downslope (red bold dotted line), and switch (red dashed line), as adapted from Immanuel et al. . (bii) T wave fitting of the repolarizing integral (RI), derived from three Hill parameters: n (red bold slope), V max (red horizontal arrow), K m (red vertical arrow) as adapted from Kanters et al. . (c) T wave features applied by the novel, proprietary T wave program , including T wave area, T wave right and left (mV/s), COG ( x / y ) of T wave; and COG of first and last 25% of T wave (ms) as adapted from Sugrue et al. . (d) T wave architectural patterns

Journal: Annals of Noninvasive Electrocardiology

Article Title: The diagnostic role of T wave morphology biomarkers in congenital and acquired long QT syndrome: A systematic review

doi: 10.1111/anec.13015

Figure Lengend Snippet: Selected T wave morphology analysis techniques. (a) ECG time intervals indicating specific T wave parameters, including Tpeak‐Tend interval (ms), T duration (ms), and T amplitude (mV). (bi) Application of sigmoidal classifiers demonstrated using Boltzmann sigmoidal functions: Upslope (red dotted line), downslope (red bold dotted line), and switch (red dashed line), as adapted from Immanuel et al. . (bii) T wave fitting of the repolarizing integral (RI), derived from three Hill parameters: n (red bold slope), V max (red horizontal arrow), K m (red vertical arrow) as adapted from Kanters et al. . (c) T wave features applied by the novel, proprietary T wave program , including T wave area, T wave right and left (mV/s), COG ( x / y ) of T wave; and COG of first and last 25% of T wave (ms) as adapted from Sugrue et al. . (d) T wave architectural patterns

Article Snippet: Sugrue et al. ( ) , N/A , 12 lead ECG Bazett formula Automated TW analysis software (MATLAB) , Novel proprietary TW program Training and validation phases Manifest and concealed LQTS TW features vs. QTc Diagnostic accuracy: Sn, Sp, NPV, PPV , Discrimination accuracy TWM Lead V 6 : Manifest LQTS: 86.8% Concealed LQTS: 83.3% TW features: Tpeak‐Tend, left slope, COG x axis Sn: 83% (manifest), 76% (concealed) Sp: 91% (manifest), 91% (concealed) PPV: 90% (manifest), 89% (concealed) NPV: 84% (manifest), 79% (concealed).

Techniques: Derivative Assay

a DBS lead construction via LeadDBS toolbox. Bilateral DBS leads accurately targeted the STN region (orange area). b , c The SOD level was obviously increased after patients received STN-DBS for six months ( P = 0.0455), nevertheless, GSH expression did not change in the same period ( P = 0.3025) ( n = 8 per time point; paired-T test). d , e Regardless of whether patients were on or off medication, the MDS-UPDRS III scores were significantly reduced after the operation ( n = 7 per time point; d: P = 0.0329; e: P = 0.0002; paired-T test). f , g There was no significant relationship between changes in antioxidant enzymes [SOD ( P = 0.8763) or GSH ( P = 0.7926)] and change in MDS-UPDRS III ( \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\frac{{({Preoperative}\,{\rm{MDS}}-{\rm{UPDRS}})}_{{med}-{off}}-{({Postoperative}\,{MDS}\,{UPDRS})}_{{stm}-{on},\,{med}-{off}}}{{({Preoperative}\,{\rm{MDS}}-{\rm{UPDRS}})}_{{med}-{off}}}\times 100 \%$$\end{document} ( P r e o p e r a t i v e MDS − UPDRS ) m e d − o f f − ( P o s t o p e r a t i v e M D S U P D R S ) s t m − o n , m e d − o f f ( P r e o p e r a t i v e MDS − UPDRS ) m e d − o f f × 100 % ) ( n = 7; Pearson correlation test). * P < 0.05; ** P < 0.01; *** P < 0.001; **** P < 0.0001. Error bars standard deviation of the mean, STN-DBS subthalamic nuclei deep brain stimulation, PD Parkinson’s disease, SOD superoxide dismutase, GSH glutathione, MDS-UPDRS Movement Disorder Society-Sponsored Revision of the Unified Parkinson’s Disease Rating Scale, ns not significant.

Journal: NPJ Parkinson's Disease

Article Title: Subthalamic nucleus deep brain stimulation alleviates oxidative stress via mitophagy in Parkinson’s disease

doi: 10.1038/s41531-024-00668-4

Figure Lengend Snippet: a DBS lead construction via LeadDBS toolbox. Bilateral DBS leads accurately targeted the STN region (orange area). b , c The SOD level was obviously increased after patients received STN-DBS for six months ( P = 0.0455), nevertheless, GSH expression did not change in the same period ( P = 0.3025) ( n = 8 per time point; paired-T test). d , e Regardless of whether patients were on or off medication, the MDS-UPDRS III scores were significantly reduced after the operation ( n = 7 per time point; d: P = 0.0329; e: P = 0.0002; paired-T test). f , g There was no significant relationship between changes in antioxidant enzymes [SOD ( P = 0.8763) or GSH ( P = 0.7926)] and change in MDS-UPDRS III ( \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\frac{{({Preoperative}\,{\rm{MDS}}-{\rm{UPDRS}})}_{{med}-{off}}-{({Postoperative}\,{MDS}\,{UPDRS})}_{{stm}-{on},\,{med}-{off}}}{{({Preoperative}\,{\rm{MDS}}-{\rm{UPDRS}})}_{{med}-{off}}}\times 100 \%$$\end{document} ( P r e o p e r a t i v e MDS − UPDRS ) m e d − o f f − ( P o s t o p e r a t i v e M D S U P D R S ) s t m − o n , m e d − o f f ( P r e o p e r a t i v e MDS − UPDRS ) m e d − o f f × 100 % ) ( n = 7; Pearson correlation test). * P < 0.05; ** P < 0.01; *** P < 0.001; **** P < 0.0001. Error bars standard deviation of the mean, STN-DBS subthalamic nuclei deep brain stimulation, PD Parkinson’s disease, SOD superoxide dismutase, GSH glutathione, MDS-UPDRS Movement Disorder Society-Sponsored Revision of the Unified Parkinson’s Disease Rating Scale, ns not significant.

Article Snippet: The lead positions in PD patients were confirmed with a MATLAB toolbox-LeadDBS (v2.1.8, https://www.lead-dbs.org ) via fusion of preoperative magnetic resonance imaging (MRI) and postoperative computed tomography (CT) , the results showed that the leads were accurately implanted into the STN (Fig. ).

Techniques: Expressing, Standard Deviation